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Isodon Extract-NS

The Garden of Naturalsolution


  • SegmentPersonal care
  • INCI nameIsodonis Japonicus Leaf/Stalk Extract
  • FunctionActive ingredients, Plant extracts
  • OriginIsodonis Japonicus, Isodon Trichocarpus

Ingredient Description

The genus Isodon is known and has been attracted much attention for being a rich source of bioactive diterpe-noids. Isodon japonicus, synonymously known as Rabdosia japonica or Scutellaria japonica, is a perennial plantgrowing in Korea, Japan, eastern China, and far-eastern Russia. Young leaves are edible, and aerial parts areused as folk medicine for the treatment of gastrointestinal disorders, tumors, and inflammatory diseases inoriental countries. In Japan, the plant is called ‘enmei-so’,which means a grass effective for the prolongation ofhuman life. The bioactive compounds isolated from I. japonicus are mainly kaurane-type diterpenoids, such as epinodosin,oridonin, nodosin, enmein, isodonal, and kamebakaurin, which were reported for their potent anti-inflammatoryactivities. They exhibit inhibitory activity on NF-κB pathway in macrophages, and they also inhibit TNF-α-inducedNF-κB activation, and nitric oxide production in LPS-induced macrophages. Besides to the anti-inflammatoryactivities, two compounds among the known kaurane-type diterpenoids, oridonin and nodosin, isolated fromthe aerial part of I. japonicus, showed melanogenesis inhibition effect on murine B16F10 melanoma cells bysuppressing cellular melanin production.


  • Company nameThe Garden of Naturalsolution
  • Legal nameThe Garden of Naturalsolution Co., Ltd.
  • HeadquartersOsan-si, Gyeonggi-do, South Korea
  • Number of employees11-50
  • DescriptionThe Garden of Naturalsolution is a leading company in the natural cosmetic ingredients market in Korea. It specializes in the development and supply of an extensive range of natural ingredients for the cosmetic and food industries. Ingredients are based on plant-sources, mushrooms, and marine plants and are mostly extracted through the ultrasonic extraction method. It offers hundreds of botanical ingredients with a wide range of oriental medicinal herbs and plants native to Korea. These ingredients are tested and proven to demonstrate anti-oxidant, anti-wrinkle, skin brightening, anti-inflammatory, and anti-microbial activities - - all of which are advantages in skincare products.
  • WebsiteCompany website